EPISODES INCLUDE
There are Monsters Among Us
Marcus' Inner Strenght
The Return of Thomas
The New Team of Marcus and Thomas
Digital World, Here We Come
The Ultimate Team No More
A Birthday Kristy Will Never Forget
The Singer's Secret
Never Meet Your Heroes
Curse This Curse-Marcus' Bad Day
The Vile Of Vilemon
The Digi-egg That Fell To Earth
The Rise of Greymon
Molecular chaperones interact with virtually every newly synthesized protein. This volume assembles a collection of reviews on molecular chaperones that is both timely and basic. The book uniquely combines the basics of the subject area with the latest results. This makes it an excellent entrance for novices into the field and is suitable for teaching purposes. It also provides a source of substantial information for experts.
The proteome consists of a complex mixture of proteins each of ! which need to be folded correctly in order to function for the health of the organism, and many of these proteins require molecular chaperones to reach the correct conformation and, in some cases, to remain in a folded form. In Molecular Chaperones: Methods and Protocols, expert researchers address a wide variety of approaches to the study these mechanisms, featuring the workings of heat shock proteins and heat shock transcription factors, in vitro and in vivo. Written in the highly successful Methods in Molecular Biology™ series format, chapters features introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.  Authoritative and cutting-edge, Molecular Chaperones: Methods and Protocols serves as an ideal guide for all scientists who wish to pursue this vital biological action and its impact on human health and disease.Rob! ert the Marquess of Haverton desires a chaperone to keep from ! falling prey to the married, widowed, and single ladies of London. The Duchess of Waverly is sympathetic to her son's predicament and helps him find a suitable female to fill the position. Miss Catherine Hayward accepts this unusual job. She is surprised to find that the need to keep her new charge from being compromised is genuine. It isn't long before her sympathetic and protective feelings give way to more pleasant, fanciful notions of sharing his company. Soon Catherine finds herself falling for her employer, the Marquess, which makes her the exact type of woman from whom he is to be protected.Originally published in 2005, this book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and! foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?Molecular chaperones recognize nascent polypeptide chains and are essential for their post-translational modification: folding, proteolytic processing, transport, intracellular targeting, and secretion. They are also implicated in normal cell growth, signal transduction and the cell's response to stress. Interest in molecular chaperones has grown ex! ponentially over the last decade. Much work has already been d! one in u nderstanding the structure and function of the major molecular chaperones, and more recently the emphasis in research has shifted toward exploring their precise roles in the many different processes with which they are involved inside the cell. This aspect of molecular chaperone biology is the focus of this book. Here, the field's leading experts synthesise our body of knowledge into succinct chapters, and the reader gains not only a fuller understanding of the roles of chaperones in the context of cellular processes, but also an insight into the nature of these proteins and their breadth of definition. This book represents an invaluable summary of the state of research in this fast-moving and highly important branch of molecular biology.The Networking of Chaperones by Co-chaperones updates the current understanding of how chaperones are regulated and networked. It is a resource for those in the specialized field of cell stress and chaperones. The book will also be of inter! est to those in broader cross-cutting field such as cellular networks and systems biology.
Featuring an all-star menagerie of voice talent (including Chris Rock, John Leguizamo, Norm MacDonald, Albert Brooks, Gary Shandling and Ellen DeGeneres), this wild and woolly free-for-all is your p! rescription for hilarious hijinks and "mischievous fun!" (The New York Times)There's something intrinsically funny about tactlessly truth-telling talking animals. And there are plenty of those--and laughs to go with them--in this 1998 reimagining of Hugh Lofting's children's story. Murphy plays the doctor in question, a modern-day San Francisco physician who discovers that he can understand what animals have to say. Director Betty Thomas makes the most of an amazing voice cast for the animals, led by Norm McDonald and including everyone from Garry Shandling to Julie Kavner to Albert Brooks. The story itself is pretty slim--will the conscientious doctor sign his soul away to a greedy HMO?--but Murphy makes the most of it, often providing priceless reactions to animal voices only he can hear. --Marshall Fine Foreword by Patricia C. McKissack and Fredrick L. McKissack. Afterword by Peter Glassman.
When a swallow arrives in Puddleby-on-the-Marsh with the news that the ! monkeys of Africa are ill and only the doctor who talks with a! nimals c an save them, Doctor Dolittle and such good friends as Jip, his loyal dog, and Dab-Dab, his housekeeper duck, face their greatest challenge. Together they must sail to Africa, battle a band of cutthroat pirates, flee across a gorge on a bridge made of acrobatic apes, and convince the king of the beasts that even he must help an animal in need. With nearly fifty full-page pictures from Michael Hague and the McKissacks artful reworking of the dilemma faced by Prince Bumpo, this treasured story is now available in a deluxe edition that all families will want to explore again and again.Doctor Dolittle--a 19th-century English physician--has never been one for worrying much. Even after his human patients desert him (when one too many sit on one of the doctor's unusual parlor pets), he manages to convert gracefully to animal medicine. Having mastered animal language along the way (with the help of his caustic yet amusing parrot, Polynesia), he has a good head start in his prac! tice. Then, one cold, dark winter night, as the doctor and his pets sit around the fire, a message arrives, via sparrow, from Africa. A terrible epidemic has broken out among the monkeys, and Doctor Dolittle is the only one who can save them. The beneficent physician checks his money box--not a penny left. But the fate of Africa's ailing apes lays squarely on his shoulders.
And so begins the delightful, whimsical adventures that are still enthralling readers three quarters of a century after their original 1920 publication. Hugh Lofting, winner of the 1923 Newbery Medal for The Voyages of Doctor Dolittle, has more than a knack for storytelling. His ability to imbue in his characters--human and animal--distinct, unique personalities is remarkable, and his respect for the rights of all who share the planet shines throughout. (Ages 9 to 12) --Emilie Coulter Get ready for the wildest adventure of a lifetime in the most ambitious musical prod! uction ever brought to film. Earning a 1967 Academy Award nomi! nation f or Best Picture, this dazzling fantasy turns both ordinary and exotic animals into talking, dancing and singing sensations! Rex Harrison is unforgettable in this inspiring adaptation of Hugh Lofting's classic stories. Step into the English country home of the good doctor as he performs remarkable treatments on the wildest variety of patients you could imagine. Discover his secret cures and watch with wide-eyed excitement as he and his four-legged, fine-feathered friends charm their way into your heart!So, they let both Rex Harrison and Anthony Newley sing. This 1968 family musical is classier than the 1998 Eddie Murphy remake, with all of its scatological humor. This won a couple of Oscars (Best Song, Best Effects) and was nominated for seven more, including Best Picture. At the time of release, however, this was a box-office dud. Based (in part) on the magical Hugh Lofting book, it begins in Puddleby-by-the-Marsh, England, from which the world-renowned veterinarian D! olittle (Harrison) begins his quest for a giant pink sea snail. Children should find this enjoyable for its exotic creatures, such as the Pushme-Pullyou. Most adults may not agree as readily, although some of us consider this a guilty pleasure. --Rochelle O'Gorman Doctor Dolittle heads for the high seas in perhaps the most amazing adventure ever experienced by man or animal.
! Though Dan is brilliant, dynamic, and in control in the classroom, he spends his time outside school on the edge of consciousness. His disappointments and disillusionment have led to a serious drug habit. He juggles his hangovers and his homework, keeping his lives separated, until one of his troubled students, Drey (Shareeka Epps), catches him getting high after school.
From this awkward beginning, Dan and Drey stumble into an unexpected friendship. Despite the differences in their ages and situations, they are both at an important intersection. Depending on which way they turn ' and which choices they make ' their lives will change.
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Sometimes people are attrac! ted to e ach other because of their differences. When there's a nebulous attraction between a teacher and a young teenage child--as in the superb Half Nelson--the relationship has all the makings of confused disaster. Though there are a few uncomfortable moments when it's not obvious whether Dan (Ryan Gosling) and Drey (Shareeka Epps) might cross the line, the attraction between the pair is culled less from sexual tension than desperation. Dan is an idealistic history teacher in an inner-city school. Drey is one of his brightest students. For both, drugs represent something that may help them escape their worlds. He takes drugs to dull his dissatisfaction with himself. She views drugs as a possible way to better her life, even though she knows her brother's foray into that trade landed him in jail. Bleakly filmed and well told, Half Nelson soars because of the immaculate acting by Gosling and Epps. With his impish smile, Gosling provides a character that is at once disa! rming, alluring, and pitiful. As the young girl who's already seen too much hardship in her life, Epps plays her part with just the right amount of hardened raw emotion. While the ambiguous ending may not please fans weaned on happy Hollywood finales, it's a fitting and believable close to a thought-provoking film. --Jae-Ha Kim
Stills from Half Nelson (click for larger image)
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Beyond Half Nelson at Amazon.com
 The Films of Ryan Gosling |  More Oscar Nominated Roles at the Amazon.com Oscar Store |  The Soundtrack |
Beyond Lars and the Real Girl
 More from Ryan Gosling |  Lars and the Real Girl Soundtrack |  More Comedies from MGM |
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