The Networking of Chaperones by Co-chaperones (Molecular Biology Intelligence Unit)

• ISBN13: 9780387493084
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In London, under the not-so-watchful eye of her chaperone, newly-arrived American Emilia Highhart is unknowingly courted by twins-and only one of them is the love of her life.Newly revised in 2007 to reflect recent industry developments!

Molecular chaperones interact with virtually every newly synthesized protein. This volume assembles a collection of reviews on molecular chaperones that is both timely and basic. The book uniquely combines the basics of the subject area with the latest results. This makes it an excellent entrance for novices into the field and is suitable for teaching purposes. It also provides a source of substantial information for experts.

The proteome consists of a complex mixture of proteins each of ! which need to be folded correctly in order to function for the health of the organism, and many of these proteins require molecular chaperones to reach the correct conformation and, in some cases, to remain in a folded form.  In Molecular Chaperones: Methods and Protocols, expert researchers address a wide variety of approaches to the study these mechanisms, featuring the workings of heat shock proteins and heat shock transcription factors, in vitro and in vivo. Written in the highly successful Methods in Molecular Biology™ series format, chapters features introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.   Authoritative and cutting-edge, Molecular Chaperones: Methods and Protocols serves as an ideal guide for all scientists who wish to pursue this vital biological action and its impact on human health and disease.Rob! ert the Marquess of Haverton desires a chaperone to keep from ! falling prey to the married, widowed, and single ladies of London. The Duchess of Waverly is sympathetic to her son's predicament and helps him find a suitable female to fill the position. Miss Catherine Hayward accepts this unusual job. She is surprised to find that the need to keep her new charge from being compromised is genuine. It isn't long before her sympathetic and protective feelings give way to more pleasant, fanciful notions of sharing his company. Soon Catherine finds herself falling for her employer, the Marquess, which makes her the exact type of woman from whom he is to be protected.Originally published in 2005, this book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and! foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?Molecular chaperones recognize nascent polypeptide chains and are essential for their post-translational modification: folding, proteolytic processing, transport, intracellular targeting, and secretion. They are also implicated in normal cell growth, signal transduction and the cell's response to stress. Interest in molecular chaperones has grown ex! ponentially over the last decade. Much work has already been d! one in u nderstanding the structure and function of the major molecular chaperones, and more recently the emphasis in research has shifted toward exploring their precise roles in the many different processes with which they are involved inside the cell. This aspect of molecular chaperone biology is the focus of this book. Here, the field's leading experts synthesise our body of knowledge into succinct chapters, and the reader gains not only a fuller understanding of the roles of chaperones in the context of cellular processes, but also an insight into the nature of these proteins and their breadth of definition. This book represents an invaluable summary of the state of research in this fast-moving and highly important branch of molecular biology.The Networking of Chaperones by Co-chaperones updates the current understanding of how chaperones are regulated and networked. It is a resource for those in the specialized field of cell stress and chaperones. The book will also be of inter! est to those in broader cross-cutting field such as cellular networks and systems biology.